1,187 research outputs found
Scattering Theory and -Symmetry
We outline a global approach to scattering theory in one dimension that
allows for the description of a large class of scattering systems and their
-, -, and -symmetries. In
particular, we review various relevant concepts such as Jost solutions,
transfer and scattering matrices, reciprocity principle, unidirectional
reflection and invisibility, and spectral singularities. We discuss in some
detail the mathematical conditions that imply or forbid reciprocal
transmission, reciprocal reflection, and the presence of spectral singularities
and their time-reversal. We also derive generalized unitarity relations for
time-reversal-invariant and -symmetric scattering
systems, and explore the consequences of breaking them. The results reported
here apply to the scattering systems defined by a real or complex local
potential as well as those determined by energy-dependent potentials, nonlocal
potentials, and general point interactions.Comment: Slightly expanded revised version, 38 page
The fitness consequences of inbreeding in natural populations and their implications for species conservation – a systematic map
Background: Threatened species often have small and isolated populations where mating among relatives can
result in inbreeding depression increasing extinction risk. Effective management is hampered by a lack of syntheses
summarising the magnitude of, and variation in inbreeding depression. Here we describe the nature and scope
of the literature examining phenotypic/fitness consequences of inbreeding, to provide a foundation for future
syntheses and management.
Methods: We searched the literature for articles documenting the impact of inbreeding in natural populations.
Article titles, abstracts and full-texts were assessed against a priori defined criteria, and information relating to study
design, quality and other factors that may influence inbreeding responses (e.g. population size) was extracted from
relevant articles.
Results: The searches identified 11457 articles, of which 614 were assessed as relevant and included in the systematic
map (corresponding to 703 distinct studies). Most studies (663) assessed within-population inbreeding resulting from
self-fertilisation or consanguineous pairings, while 118 studies assessed among-population inbreeding due to drift load.
Plants were the most studied taxon (469 studies) followed by insects (52 studies) and birds (43 studies). Most studies
investigated the effects of inbreeding on components of fitness (e.g. survival or fecundity; 648 studies) but measurements
were typically under laboratory/greenhouse conditions (486 studies). Observations were also often restricted to the first
inbred generation (607 studies) and studies frequently lacked contextual information (e.g. population size).
Conclusions: Our systematic map describes the scope and quality of the evidence describing the phenotypic
consequences of inbreeding. The map reveals substantial evidence relating to inbreeding responses exists,
but highlights information is still limited for some aspects, including the effects of multiple generations of
inbreeding. The systematic map allowed us to define several conservation-relevant questions, where sufficient
data exists to support systematic reviews, e.g. How do inbreeding responses vary with population size? However,
we found that such syntheses are likely to be constrained by incomplete reporting of critical contextual information.
Our systematic map employed the same rigorous literature assessment methods as systematic review, including a
novel survey of study quality and thus provides a robust foundation to guide future research and syntheses seeking to
inform conservation decision-making
Technological literacy reconsidered: a model for enactment
The final publication is available at: http://link.springer.com/article/10.1007%2Fs10798-009-9108-6.This paper presents a model to describe technological literacy as enacted by individuals in the course of shaping their lives and the world around them. The model has two interrelated facets – the potential for and enactment of technological literacy – where enactment and potential mutually constitute each other. This potential is made up of knowledge of a particular situation, personal engagement with a situation, and social engagement in the world. Enactment requires a particular set of competencies in action, which together helps shape the situation: recognizing needs; articulating problems; contributing towards the technological process; and analysing consequences. The implications of this model for technological literacy in the context of the individual and society, and the role of technology education in developing technological literacy, are discussed
Trends in Compulsory Licensing of Pharmaceuticals Since the Doha Declaration: A Database Analysis
Reed Beall and Randall Kuhn describe their findings from an analysis of use of compulsory licenses for pharmaceutical products by World Trade Organization members since 1995
An instrument to determine the technological literacy levels of upper secondary school students
In this article, an instrument for assessing upper secondary school students’
levels of technological literacy is presented. The items making up the instrument emerged
from a previous study that employed a phenomenographic research approach to explore
students’ conceptions of technology in terms of their understanding of the nature of
technology and their interaction with technological artefacts. The instrument was validated
through administration to 1,245 students on completion of their 12 years of formal
schooling. A factor analysis was conducted on the data and Cronbach alpha reliability coefficients
determined. The results show that a five-dimension factor structure (namely,
artefact, process, direction/instruction, tinkering, and engagement) strongly supported the
dimensions as developed during the original phenomenographic study. The Cronbach
alpha reliability co-efficient of each dimension was satisfactory. Based on these findings,
the instrument has been shown to be valid and reliable and can be used with confidence
Massive stars as thermonuclear reactors and their explosions following core collapse
Nuclear reactions transform atomic nuclei inside stars. This is the process
of stellar nucleosynthesis. The basic concepts of determining nuclear reaction
rates inside stars are reviewed. How stars manage to burn their fuel so slowly
most of the time are also considered. Stellar thermonuclear reactions involving
protons in hydrostatic burning are discussed first. Then I discuss triple alpha
reactions in the helium burning stage. Carbon and oxygen survive in red giant
stars because of the nuclear structure of oxygen and neon. Further nuclear
burning of carbon, neon, oxygen and silicon in quiescent conditions are
discussed next. In the subsequent core-collapse phase, neutronization due to
electron capture from the top of the Fermi sea in a degenerate core takes
place. The expected signal of neutrinos from a nearby supernova is calculated.
The supernova often explodes inside a dense circumstellar medium, which is
established due to the progenitor star losing its outermost envelope in a
stellar wind or mass transfer in a binary system. The nature of the
circumstellar medium and the ejecta of the supernova and their dynamics are
revealed by observations in the optical, IR, radio, and X-ray bands, and I
discuss some of these observations and their interpretations.Comment: To be published in " Principles and Perspectives in Cosmochemistry"
Lecture Notes on Kodai School on Synthesis of Elements in Stars; ed. by Aruna
Goswami & Eswar Reddy, Springer Verlag, 2009. Contains 21 figure
Expression of BNIP3 in invasive breast cancer: correlations with the hypoxic response and clinicopathological features
<p>Abstract</p> <p>Background</p> <p>Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) is a pro-apoptotic member of the Bcl-2 family induced under hypoxia. Low or absent expression has recently been described in human tumors, including gastrointestinal tumors, resulting in poor prognosis. Little is known about BNIP3 expression in invasive breast cancer. The aim of the present study was to investigate the expression of BNIP3 in invasive breast cancer at the mRNA and protein level in correlation with the hypoxic response and clinicopathological features.</p> <p>Methods</p> <p>In 40 cases of invasive breast cancer, BNIP3 mRNA <it>in situ </it>hybridization was performed on frozen sections with a digoxigenin labeled anti-BNIP3 probe. Paraffin embedded sections of the same specimens were used to determine protein expression of BNIP3, Hypoxia Inducible Factor 1 alpha (HIF-1α) and its downstream targets Glucose Transporter 1 (Glut-1) and Carbonic Anhydrase (CAIX) by immunohistochemistry.</p> <p>Results</p> <p>BNIP3 mRNA was expressed in 16/40 (40%) of the cases and correlated with BNIP3 protein expression (p = 0.0218). Neither BNIP3 protein nor mRNA expression correlated with expression of HIF-1α expression or its downstream targets. Tumors which showed loss of expression of BNIP3 had significantly more often lymph node metastases (82% vs 39%, p = 0.010) and showed a higher mitotic activity index (p = 0.027). BNIP3 protein expression was often nuclear in normal breast, but cytoplasmic in tumor cells.</p> <p>Conclusion</p> <p>BNIP3 expression is lost in a significant portion of invasive breast cancers, which is correlated with poor prognostic features such as positive lymph node status and high proliferation, but not with the hypoxic response.</p
Perspectives of San Juan healthcare practitioners on the detection deficit in oral premalignant and early cancers in Puerto Rico: a qualitative research study
<p>Abstract</p> <p>Background</p> <p>In Puerto Rico, relative to the United States, a disparity exists in detecting oral precancers and early cancers. To identify factors leading to the deficit in early detection, we obtained the perspectives of San Juan healthcare practitioners whose practice could be involved in the detection of such oral lesions.</p> <p>Methods</p> <p>Key informant (KI) interviews were conducted with ten clinicians practicing in or around San Juan, Puerto Rico. We then triangulated our KI interview findings with other data sources, including recent literature on oral cancer detection from various geographic areas, current curricula at the University of Puerto Rico Schools of Medicine and Dental Medicine, as well as local health insurance regulations.</p> <p>Results</p> <p>Key informant-identified factors that likely contribute to the detection deficit include: many practitioners are deficient in knowledge regarding oral cancer and precancer; oral cancer screening examinations are limited regarding which patients receive them and the elements included. In Puerto Rico, specialists generally perform oral biopsies, and patient referral can be delayed by various factors, including government-subsidized health insurance, often referred to as Reforma. Reforma-based issues include often inadequate clinician knowledge regarding Reforma requirements/provisions, diagnostic delays related to Reforma bureaucracy, and among primary physicians, a perceived financial disincentive in referring Reforma patients.</p> <p>Conclusions</p> <p>Addressing these issues may be useful in reducing the deficit in detecting oral precancers and early oral cancer in Puerto Rico.</p
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